Volume 10 Supplement 7
LSI based framework to predict gene regulatory information
© Roy et al; licensee BioMed Central Ltd. 2009
Published: 25 June 2009
Results and discussion
The LSI-based algorithm allows prediction of TFs based on latent (implicit) relationships in the literature. A preliminary evaluation of our method using previously published knock-out experiments revealed that it has reasonable recall and precision. A more rigorous evaluation of the method will require several additional TF knock-out microarray experiments. This work provides proof of principle that the combination of motif analysis and LSI may be used to identify putative transcriptional modules from microarray data.
This article is published under license to BioMed Central Ltd.