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Table 5 Loci-sets with unadjusted p-value no greater than 0.1% in the antihypertensive response example

From: GLOSSI: a method to assess the association of genetic loci-sets with complex diseases

Loci-set MsigDB ID No. SNP No. relevant gene p-value q-value
Non-Hispanic white      
   TPO signaling pathway c2:338 48 10 0.0001 0.035
   Erk1/Erk2 Mapk signaling pathway c2:178 74 16 0.0001 0.035
   Sprouty regulation of tyrosine kinase signals c2:316 36 10 0.0001 0.035
   Multiple antiapoptotic pathways from IGF-1R signaling lead to bad phosphorylation c2:214 24 8 0.0002 0.035
   PTEN pathway c2:557 30 8 0.0002 0.035
   Transcription factor CREB and its extracellular signals c2:152 83 16 0.0002 0.035
   Growth hormone signaling pathway c2:198 50 11 0.0002 0.035
   PTEN dependent cell cycle arrest and apoptosis c2:292 24 8 0.0003 0.035
   Upregulated in acute rejection transplanted kidney biopsies c2:834 132 25 0.0003 0.035
   IL 3 signaling pathway c2:223 18 6 0.0003 0.035
   Trka receptor signaling pathway c2:339 41 5 0.0003 0.035
   IL-2 receptor beta chain in T cell activation c2:222 40 11 0.0004 0.035
   B cell antigen receptor c2:569 49 18 0.0004 0.035
   IL 4 receptor signaling in B lymphocytes c2:563 39 12 0.0004 0.035
   Calcium signaling by HBx of Hepatitis B virus c2:569 16 4 0.0005 0.035
   Glycogen processing c2:602 39 8 0.0005 0.035
   IGF-1 signaling pathway c2:213 31 9 0.0005 0.035
   Down regulated following Apc loss c2:1048 156 32 0.0005 0.035
   Liver selective c2:979 300 104 0.0005 0.035
   TrkA receptor c2:559 19 6 0.0006 0.035
   Inhibition of cellular proliferation by gleevec c2:199 37 10 0.0006 0.035
   IL 6 signaling pathway c2:226 25 8 0.0006 0.035
   Insulin signaling pathway c2:229 26 8 0.0007 0.039
   Upregulated in fibroblasts following infection with human cytomegalovirus c2:1269 131 24 0.0008 0.040
   Down regulated by both curcumin and sulindac in SW260 colon carcinoma cells c2:1412 50 10 0.0010 0.047
   Upregulated by TPA in resistant HL-525 cells c2:1679 90 19 0.0010 0.048
African American      
   Upregulated by UV-B light in epidermal keratinocytes c2:1717 55 12 0.0004 0.56
   Upregulated in well functioning transplanted kidney biopsies c2:836 1347 285 0.0009 0.63