Table 5 Loci-sets with unadjusted p-value no greater than 0.1% in the antihypertensive response example
From: GLOSSI: a method to assess the association of genetic loci-sets with complex diseases
| Loci-set | MsigDB ID | No. SNP | No. relevant gene | p-value | q-value |
|---|---|---|---|---|---|
| Non-Hispanic white | |||||
| TPO signaling pathway | c2:338 | 48 | 10 | 0.0001 | 0.035 |
| Erk1/Erk2 Mapk signaling pathway | c2:178 | 74 | 16 | 0.0001 | 0.035 |
| Sprouty regulation of tyrosine kinase signals | c2:316 | 36 | 10 | 0.0001 | 0.035 |
| Multiple antiapoptotic pathways from IGF-1R signaling lead to bad phosphorylation | c2:214 | 24 | 8 | 0.0002 | 0.035 |
| PTEN pathway | c2:557 | 30 | 8 | 0.0002 | 0.035 |
| Transcription factor CREB and its extracellular signals | c2:152 | 83 | 16 | 0.0002 | 0.035 |
| Growth hormone signaling pathway | c2:198 | 50 | 11 | 0.0002 | 0.035 |
| PTEN dependent cell cycle arrest and apoptosis | c2:292 | 24 | 8 | 0.0003 | 0.035 |
| Upregulated in acute rejection transplanted kidney biopsies | c2:834 | 132 | 25 | 0.0003 | 0.035 |
| IL 3 signaling pathway | c2:223 | 18 | 6 | 0.0003 | 0.035 |
| Trka receptor signaling pathway | c2:339 | 41 | 5 | 0.0003 | 0.035 |
| IL-2 receptor beta chain in T cell activation | c2:222 | 40 | 11 | 0.0004 | 0.035 |
| B cell antigen receptor | c2:569 | 49 | 18 | 0.0004 | 0.035 |
| IL 4 receptor signaling in B lymphocytes | c2:563 | 39 | 12 | 0.0004 | 0.035 |
| Calcium signaling by HBx of Hepatitis B virus | c2:569 | 16 | 4 | 0.0005 | 0.035 |
| Glycogen processing | c2:602 | 39 | 8 | 0.0005 | 0.035 |
| IGF-1 signaling pathway | c2:213 | 31 | 9 | 0.0005 | 0.035 |
| Down regulated following Apc loss | c2:1048 | 156 | 32 | 0.0005 | 0.035 |
| Liver selective | c2:979 | 300 | 104 | 0.0005 | 0.035 |
| TrkA receptor | c2:559 | 19 | 6 | 0.0006 | 0.035 |
| Inhibition of cellular proliferation by gleevec | c2:199 | 37 | 10 | 0.0006 | 0.035 |
| IL 6 signaling pathway | c2:226 | 25 | 8 | 0.0006 | 0.035 |
| Insulin signaling pathway | c2:229 | 26 | 8 | 0.0007 | 0.039 |
| Upregulated in fibroblasts following infection with human cytomegalovirus | c2:1269 | 131 | 24 | 0.0008 | 0.040 |
| Down regulated by both curcumin and sulindac in SW260 colon carcinoma cells | c2:1412 | 50 | 10 | 0.0010 | 0.047 |
| Upregulated by TPA in resistant HL-525 cells | c2:1679 | 90 | 19 | 0.0010 | 0.048 |
| African American | |||||
| Upregulated by UV-B light in epidermal keratinocytes | c2:1717 | 55 | 12 | 0.0004 | 0.56 |
| Upregulated in well functioning transplanted kidney biopsies | c2:836 | 1347 | 285 | 0.0009 | 0.63 |