Figure 1
From: dbSMR: a novel resource of genome-wide SNPs affecting microRNA mediated regulation
miRNA-mRNA interaction model. a: Case a: miRNA binding site in loop region of mRNA (Favorable), Case b: miRNA binding site in stem region of mRNA (Unfavorable), Case c: miRNA binding site in stem-loop junction (Sequence Dependent). b: The validated binding site for miR-15a/miR-16 in the 3' UTR of BCL2 was found to be accessible with the wild type allele, but the A-to-G polymorphism alters the intramolecular structure at the target site which could prove to be altering the accessibility of the miRNA to bind. The shaded region indicates miRNA binding site. c: The validated binding site for hsa-miR-24 in the 3' UTR of DHFR gene with 'U' allele 14 bp downstream is structured and hence, inaccessible for miRNA binding while the 'C' allele makes the target site totally unstructured thereby allowing miRNA binding.