Connections between the schizophrenia risk genes DTNBP1 and NRG1. (A) DLG4 and EXOC4 are positioned on the path between DTNBP1 and NRG1. Without DLG4 and EXOC4, the links between DTNBP1 and NRG1 would be broken. The gene expression patterns of the nodes in the temporal lobe are labeled with differential levels of grey, where darker shades denote higher expression levels. This figure is generated using CytoScape. The same network in two brain tissues, (B) Prefrontal Cortex and (C) Temporal Lobe, reveal the presences of interactions among DTNBP1, DLG4 and EXOC4. (D) Whereas in adipocyte (which is not related to brain and schizophrenia), most of the interactions are missing.