Distributions of putative midbody proteins in the top 30 mediators ranked by the sub-network specificity score (S3) and the degree centrality. Four types of proteins are considered as putative midbody proteins, including actin-related, cytokinesis-related, membrane associated, and rho proteins. Other proteins with unrelated annotations were classified as unknown. As compared to degree centrality, S3 can enrich the proportion of putative midbody proteins into the top-ranked mediators. This implies that the ranking given by S3 could be used to refine the composition of the midbody proteome.