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Table 2 Protein-protein interaction data sources incorporated in POINeT.

From: POINeT: protein interactome with sub-network analysis and hub prioritization

Data Source

Version or Download Date

Number of Interactions Included

References

References Details

BioGRID

2.0.37

202,244

Stark et al. (2006)

Stark, C., Breitkreutz, B.J., Reguly, T., et al. (2006) BioGRID: a general repository for interaction datasets, Nucleic Acids Res, 34, D535–539.

IntACT

2008/2/11

121,560

Hermjakob et al. (2004)

Hermjakob, H., Montecchi-Palazzi, L., Lewington, C., et al. (2004) IntAct: an open source molecular interaction database, Nucleic Acids Res, 32, D452–455.

HPRD

version 7

37,107

Peri, S. et al. (2003)

Peri, S. et al. (2003) Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Research. 13:2363–2371.

MPact

2005/12/22

12,955

Ulrich G. et al. (2006)

Güldener U, Münsterkötter M, Oesterheld M, Pagel P, Ruepp A, Mewes HW, Stümpflen V(2006). MPact: the MIPS protein interaction resource on yeast. Nucl. Acids Res. 2006 34: D436–D441

DIP

2008/1/14

50,048

Xenarios et al. (2000)

Xenarios, I., Rice, D.W., Salwinski, L., et al. (2000) DIP: the database of interacting proteins, Nucleic Acids Res, 28, 289–291.

MINT

4.0

99,773

Zanzoni et al. (2002)

Zanzoni, A., Montecchi-Palazzi, L., Quondam, M., et al. (2002) MINT: a Molecular INTeraction database, FEBS Lett, 513, 135–140.

CYGD

2007/1/25

33,984

Guldener et al. (2005)

Guldener, U., Munsterkotter, M., Kastenmuller, G., et al. (2005) CYGD: the Comprehensive Yeast Genome Database, Nucleic Acids Res, 33, D364–368.

BIND

2006/5/25

41,603

Bader et al. (2003)

Bader, G.D., Betel, D. and Hogue, C.W. (2003) BIND: the Biomolecular Interaction Network Database, Nucleic Acids Res, 31, 248–250.

MIPS

2007/1/1

1,363

Mewes et al. (2004)

Mewes, H.W., Amid, C., Arnold, R., et al. (2004) MIPS: analysis and annotation of proteins from whole genomes, Nucleic Acids Res, 32, D41–44.

  1. The numbers of PPIs from various data sources as collected by POINeT. The total number of PPIs is not the sum of all PPIs from various sources since there are numerous redundant entries.