Skip to main content

Table 3 Top30 mediators with prioritized sorting excluding midbody queries.

From: POINeT: protein interactome with sub-network analysis and hub prioritization

Ranks by Hub Degree Gene Symbol Hub Degree Total Degree Annotation Ranks by S3 Score Gene Symbol Hub Degree Total Degree Annotation
1 GRB2 36 407   1 HTR3A 2 2 membrane
2 YWHAZ 27 391   2 KIAA0133 2 2 membrane
3 IKBKE 24 328   3 PPP1R14B 2 2  
4 TRAF6 24 369   4 DOCK7 2 3 Rho
5 HLA-B 20 273 membrane 5 GEFT 2 3 Rho
6 MAP3K3 18 173   6 LCT 2 3 membrane
7 ACTB 17 187   7 OPHN1 2 3 Rho
8 YWHAG 16 309   8 PLEKHG2 2 3 Rho
9 RIPK3 15 88   9 MYT1 2 3  
10 IKBKG 15 155 cytokinesis 10 PLEKHM2 2 3 membrane
11 MCC 14 217   11 TOR1AIP1 2 3 membrane
12 EGFR 14 261 membrane 12 MALL 2 3 membrane
13 MYC 13 322   13 ARPC5 5 9 actin
14 TP53 12 315 cytokinesis 14 FLOT2 3 6 membrane
15 CASP3 11 139   15 ESPL1 2 4 cytokinesis
16 EIF1B 11 153   16 ASPM 2 4 cytokinesis
17 CDH1 10 80 membrane 17 CASC3 2 4 membrane
18 PRKCA* 10 181 Rho 18 CD163 2 4 membrane
19 VHL 10 208 membrane 19 MCF2L 2 4 Rho
20 SRC 10 217 cytokinesis 20 DIS3L2 2 4  
21 ACTA1 9 103 actin 21 KTN1 3 7 cytokinesis
22 DISC1 9 113   22 ARPC4 5 13 actin
23 EPB41 9 128   23 SRGAP1 2 5 Rho
24 TNFRSF1A 9 128   24 RPRM 2 5 membrane
25 CFTR 9 135 membrane 25 SEC24D 2 5  
26 PRKAB1 9 153   26 NRAP 2 5 actin
27 FYN 9 161 cytokinesis 27 PLP1 2 5 membrane
28 SMAD3 9 193   28 SEPT11 2 5 cytokinesis
29 GH1 8 76   29 ABCC2 2 5 membrane
30 EIF6 8 101   30 ACP6 3 9 membrane
Putative Midbody Related Proteins 11 (37%) Putative Midbody Related Proteins 26 (87%)
  Actin   1 (3%)   Actin   3 (10%)
  Cytokinesis   4 (13%)   Cytokinesis   4 (13%)
  Membrane   5 (17%)   Membrane   13 (43%)
  Rho proteins   1 (3%)   Rho proteins   6 (20%)
Unknown Proteins   19 (63%) Unknown Proteins   4 (13%)
  1. The top 30 proteins ranked by hub degree (left) and sub-network specificity score (S3, right) and analyzed for their ability to enrich midbody-related proteins.
  2. * PRKCA is both a Rho protein and a cytokinesis related protein. It is classified as Rho protein to simplify the ratio calculation.