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Table 3 Top30 mediators with prioritized sorting excluding midbody queries.

From: POINeT: protein interactome with sub-network analysis and hub prioritization

Ranks by Hub Degree

Gene Symbol

Hub Degree

Total Degree

Annotation

Ranks by S3 Score

Gene Symbol

Hub Degree

Total Degree

Annotation

1

GRB2

36

407

 

1

HTR3A

2

2

membrane

2

YWHAZ

27

391

 

2

KIAA0133

2

2

membrane

3

IKBKE

24

328

 

3

PPP1R14B

2

2

 

4

TRAF6

24

369

 

4

DOCK7

2

3

Rho

5

HLA-B

20

273

membrane

5

GEFT

2

3

Rho

6

MAP3K3

18

173

 

6

LCT

2

3

membrane

7

ACTB

17

187

 

7

OPHN1

2

3

Rho

8

YWHAG

16

309

 

8

PLEKHG2

2

3

Rho

9

RIPK3

15

88

 

9

MYT1

2

3

 

10

IKBKG

15

155

cytokinesis

10

PLEKHM2

2

3

membrane

11

MCC

14

217

 

11

TOR1AIP1

2

3

membrane

12

EGFR

14

261

membrane

12

MALL

2

3

membrane

13

MYC

13

322

 

13

ARPC5

5

9

actin

14

TP53

12

315

cytokinesis

14

FLOT2

3

6

membrane

15

CASP3

11

139

 

15

ESPL1

2

4

cytokinesis

16

EIF1B

11

153

 

16

ASPM

2

4

cytokinesis

17

CDH1

10

80

membrane

17

CASC3

2

4

membrane

18

PRKCA*

10

181

Rho

18

CD163

2

4

membrane

19

VHL

10

208

membrane

19

MCF2L

2

4

Rho

20

SRC

10

217

cytokinesis

20

DIS3L2

2

4

 

21

ACTA1

9

103

actin

21

KTN1

3

7

cytokinesis

22

DISC1

9

113

 

22

ARPC4

5

13

actin

23

EPB41

9

128

 

23

SRGAP1

2

5

Rho

24

TNFRSF1A

9

128

 

24

RPRM

2

5

membrane

25

CFTR

9

135

membrane

25

SEC24D

2

5

 

26

PRKAB1

9

153

 

26

NRAP

2

5

actin

27

FYN

9

161

cytokinesis

27

PLP1

2

5

membrane

28

SMAD3

9

193

 

28

SEPT11

2

5

cytokinesis

29

GH1

8

76

 

29

ABCC2

2

5

membrane

30

EIF6

8

101

 

30

ACP6

3

9

membrane

Putative Midbody Related Proteins

11

(37%)

Putative Midbody Related Proteins

26

(87%)

 

Actin

 

1

(3%)

 

Actin

 

3

(10%)

 

Cytokinesis

 

4

(13%)

 

Cytokinesis

 

4

(13%)

 

Membrane

 

5

(17%)

 

Membrane

 

13

(43%)

 

Rho proteins

 

1

(3%)

 

Rho proteins

 

6

(20%)

Unknown Proteins

 

19

(63%)

Unknown Proteins

 

4

(13%)

  1. The top 30 proteins ranked by hub degree (left) and sub-network specificity score (S3, right) and analyzed for their ability to enrich midbody-related proteins.
  2. * PRKCA is both a Rho protein and a cytokinesis related protein. It is classified as Rho protein to simplify the ratio calculation.
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BMC Bioinformatics

ISSN: 1471-2105

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