Effect of LD between markers on multipoint parametric heterogeneity LOD scores on chromosome 2 and 6. Multipoint analysis by Allegro (intervals of 100–500 bp, confidence score < 0.02, and HWE > 0.05) were conducted with strict LD settings (D' = r2 = 0.2) or without settings. Results of chromosome 2 and 6 were shown. DNAs obtained from four affected sibling pairs were analyzed by Genome-Wide Human SNP array 6.0. SNP IDs of five loci were extracted. Colored SNP IDs are those eliminated in analysis with LD settings.