Table 1 Comparison between feature-based and general localization tools according to the validation metrics.
From: Validating subcellular localization prediction tools with mycobacterial proteins
Feature-based tools | General localization tools | |||||
|---|---|---|---|---|---|---|
Parameters | SignalP 2.0, TatP 1.0, LipoP 1.0 | SignalP 2.0 | Phobius | PA-SUB 2.5 | Gpos-PLoc | PSORTb v.2.0.4 |
TPs | 91 | 87 | 55 | 204 | 147 | 145 |
TNs | 65 | 65 | 64 | 68 | 53 | 56 |
FPs | 3 | 3 | 4 | 0 | 14 | 1.0 |
FNs | 113 | 117 | 149 | 0 | 57 | 14 |
Specificity | 0.97 | 0.97 | 0.93 | 1.0 | 0.91 | 0.99 |
Sensitivity | 0.45 | 0.43 | 0.27 | 1.0 | 0.72 | 0.91 |
MCC | 0.37 | 0.35 | 0.22 | 1.0 | 0.45 | 0.84 |
Summatory | ||||||
Secreted (TPs+FNs) | 204 | 204 | 204 | 204 | 204 | 159 |
Non secreted (TNs+FPs) | 68 | 68 | 68 | 68 | 67 | 57 |