ROC for different rule based systems on the out-of-sample HIV-1 PR 3261 – detail. Detail of the receiver operator characteristic (ROC) for the OSRE rules' accuracy on the out-of-sample HIV-1 PR 3261 data set. The squares and the crosses are the results for Table 4 and Fig. 1a in . The squares show the results when using 1, 2, 3, ..., and 10 rules from Fig. 1a in  and the crosses for Table 4 in . The dots show the prediction accuracy for the HIVcleave web-server . The solid curve shows the ROC curve for the hitherto best predictor, a linear support vector machine trained on the HIV-1 PR 1625 data set , which does not provide any rules. The dashed diagonal line marks the expected results for random prediction.