Figure 3

An integrated model of transcriptional modules in S. pombe cell cycle. (a) A map of the unified model topology. Shown are fifteen modules (red nodes) and four regulators (yellow nodes) and their regulatory connections (thick edges) along the S. pombe cell cycle. The angular position and the radial distance of each module node represent the respective average peak phase and the average amplitude of transcription rates among the module members. The angular position of each regulator node represents the peak phase of its activity profile. Known cell cycle regulators that could be associated with a particular module (as members) are denoted within the module node (transcription factors – white; kinases – green). The blue edge signifies a repressive regulatory connection, while all the other connections are activatory. The thin edges connect modules with binding motifs that are significantly enriched in the module's promoters (see Additional file 3). (b) Inferred activity profiles of the four regulators R1-R4 in the unified model. Mean and one standard deviation curves are shown. (c) Zoom-in of the middle time series (Elutriation 2) in (b).