Skip to main content

Table 3 GAGE applied to the BMP6-MSC dataset of small sample size

From: GAGE: generally applicable gene set enrichment for pathway analysis

Experimental Sets

t-statistic

p-value

q-value

P.exp1

P.exp2

Ifna_Hcmv_6hrs_Up

-3.80

2.9E-07

2.9E-04

3.7E-04

1.6E-04

Der_Ifnb_Up

-3.47

1.6E-06

8.1E-04

3.3E-03

1.1E-04

Baf57_Bt549_Dn

-3.09

1.4E-05

0.005

7.2E-03

5.2E-04

Ifn_Beta_Up

-2.92

5.4E-05

0.012

1.2E-02

1.3E-03

Sana_Ifng_Endothelial_Up

-2.88

6.6E-05

0.014

1.2E-02

1.7E-03

Ifn_Any_Up

-2.76

1.1E-04

0.019

2.4E-02

1.4E-03

Dac_Bladder_Up

-2.65

2.8E-04

0.036

2.4E-03

4.0E-02

Grandvaux_Ifn_Not_Irf3_Up

-2.76

2.8E-04

0.037

3.8E-02

2.6E-03

Ifna_Uv-Cmv_Common_Hc

-2.55

5.1E-04

0.056

1.6E-02

1.1E-02

Bennett_Sle_Up

-2.48

7.3E-04

0.071

1.4E-02

2.0E-02

Canonical Pathways

t-statistic

p-value

q-value

P.exp1

P.exp2

Tgf_Beta_Signaling_Pathway

3.15

2.2E-05

0.009

1.2E-03

1.3E-03

Wnt_Signaling

2.47

5.9E-04

0.099

3.2E-03

1.7E-02

Alkpathway

2.46

8.8E-04

0.11

9.8E-03

8.7E-03

Proliferation_Genes

2.27

1.3E-03

0.13

6.8E-03

1.9E-02

Cell_Proliferation

2.24

1.5E-03

0.15

2.1E-02

7.5E-03

Hematopoesis_Related_Trans

2.05

3.9E-03

0.31

1.8E-02

2.5E-02

Erythpathway

1.98

7.5E-03

0.46

2.7E-02

3.5E-02

Smooth_Muscle_Contraction

1.79

1.0E-02

0.54

2.7E-02

5.2E-02

Apoptosis

1.73

1.3E-02

0.60

7.1E-02

2.5E-02

Breast_Cancer_Estrogen_Signaling

1.61

2.0E-02

0.69

8.1E-02

3.6E-02

  1. Top 10 most significantly differentially expressed experimental sets and canonical pathways were inferred by GAGE from human MSCs following an 8 hour BMP6 treatment. Two replicate experiments were done, each with BMP6 treated sample and control. Therefore GAGE was applied to each experiment and derived corresponding p-values (P.exp1–2). Gene sets were ranked based on global p-values from both experiments. FDR q-values were estimated to correct the global p-values for the multiple testing issue.