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Table 1 Fpocket performance

From: Fpocket: An open source platform for ligand pocket detection

Dataset

Algorithm

Rank 1

Rank 3

  

unbound

bound

unbound

bound

Pocket Picker

     
 

Fpocket

69 (67)

83 (85)

94 (92)

92 (92)

 

PocketPicker

69

72

85

85

 

LIGSITE(CS)

60

69

77

87

 

LIGSITE

58

69

75

87

 

CAST

58

67

75

83

 

PASS

60

63

71

81

 

SURFNET

52

54

75

78

 

LIGSITE(CSC)

71

79

-

-

Cheng et al.

     
 

Fpocket

-

75 (70)

-

95 (90)

 

PocketPicker

-

70

-

80

Astex Diverse set

     
 

Fpocket

-

67 (73)

-

82 (88)

 

PocketPicker

-

59

-

67

  1. Comparison of results obtained for fpocket and other approaches. For sake of comparison, scores are reported using the PPc, and we present scores at rank 1 and 3 (true pocket in the top 3 pockets proposed by fpocket). For the Pocket Picker dataset, results are taken from [23] for all but fpocket. For fpocket, numbers within parentheses correspond to scores obtained using the MOc.