Table 4 Association analysis of disease status and copy number category using the true copy number status and the estimated status obtained using the finite mixture proposed.
True CN | Estimated CN | ||||||
|---|---|---|---|---|---|---|---|
Co | Ca | OR (CI95%) | Co | Ca | ORnaïve (CI95%) | ORLC (CI95%) | |
Gene 1 | |||||||
0 | 210 | 216 | 1 | 210 | 216 | 1 | 1 |
1 | 75 | 126 | 1.63 (1.16,2.30) | 75 | 126 | 1.63 (1.16,2.30) | 1.63 (1.16,2.30) |
2 | 6 | 18 | 2.92 (1.14,7.49) | 6 | 18 | 2.92 (1.14,7.49) | 2.92 (1.14,7.50) |
P association | 0.0027 | 0.0027 | 0.0023 | ||||
P trend | 5.0 × 10-4 | 5.0 × 10-4 | 5.0 × 10-4 | ||||
Gene 2 | |||||||
0 | 24 | 66 | 1 | 22 | 63 | 1 | 1 |
1 | 159 | 201 | 0.46 (0.27,0.77) | 129 | 178 | 0.44 (0.26,0.75) | 0.47 (0.27,0.82) |
2 | 108 | 93 | 0.31 (0.18,0.54) | 140 | 119 | 0.33 (0.19,0.57) | 0.31 (0.18,0.54) |
P association | 7.2 × 10-5 | 2.3 × 10-4 | 8.4 × 10-5 | ||||
P trend | 2.1 × 10-5 | 1.0 × 10-4 | 2.1 × 10-5 | ||||