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Table 5 Steps used to assess association between CNVs and traits when aCGH is used.

From: Accounting for uncertainty when assessing association between copy number and disease: a latent class model

Step 1. Use any aCGH calling procedure that provides MAP (uncertainty)

Step 2. Build blocks/regions of consecutive probes with similar signatures

Step 3. Use the signature that occurs most in a block to perform association unsing LC model

Step 4. Correct for multiple testing considering dependency among signatures

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BMC Bioinformatics

ISSN: 1471-2105

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