Figure 1

Overview of the structural motifs identified in the PDB. a) Distribution of the score associated to the presence of shared ligand fragments (see "Identification of shared ligand atoms") for the 1227 structural motifs identified. 570 motifs had a score of zero (i.e. they were not associated to a common ligand fragment) and were therefore discarded in the subsequent analyses. The bars are coloured according to the number of folds possessing the motif. b) Distribution of the number of folds sharing the motif for the 657 motifs with score > = 1 (i.e. associated to a definite ligand fragment). c) Distribution of the ratio of the number of folds having a structural motif associated to a shared ligand fragment to the total number of folds having the motif, i.e. including those for which the motif binds a different ligand fragment. This figure does not include motifs shared by two folds only since in that case the ratio is 1 by definition. d) Distribution of the ratio of the size of the common fragment to the size of the whole representative ligand for each motif. Values of 1.0 are associated to metal atoms.