Figure 3

Constructing and tailoring natural products. Genome sequence data is translated and the NP.searcher uses BLAST to find NRPS and PKS gene clusters. BLAST is further used to find motifs of the adenylation and acyltransferase domains as well as auxiliary domains that function during chain assembly to build the core molecule. BLAST is also used to identify enzymes involved in tailoring the molecule following core molecule assembly.