Figure 3From: Improved homology-driven computational validation of protein-protein interactions motivated by the evolutionary gene duplication and divergence hypothesisNumber of Homologous PPIs. Percentage of GSP PPIs (Combined data set, left bars) and GSN PPIs (Random data set, right bars) with a certain number of homologous PPIs (A), paralogous PPIs (B), and orthologous PPIs (C). We investigated eight distinct E-value windows (x-axis) and used PSI-BLAST to determine the number of homologous PPIs within each of these windows (y-axis, numbers not cumulative). Each bar is composed of four distinct groups: the percentage of PPIs with a single identified homologous PPI, the percentage with 2 to 10 homologous PPIs, the percentage with 11 to 100 homologous PPIs, and the percentage with more than 100 identified homologous PPIs.Back to article page