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Figure 3 | BMC Bioinformatics

Figure 3

From: Improved homology-driven computational validation of protein-protein interactions motivated by the evolutionary gene duplication and divergence hypothesis

Figure 3

Number of Homologous PPIs. Percentage of GSP PPIs (Combined data set, left bars) and GSN PPIs (Random data set, right bars) with a certain number of homologous PPIs (A), paralogous PPIs (B), and orthologous PPIs (C). We investigated eight distinct E-value windows (x-axis) and used PSI-BLAST to determine the number of homologous PPIs within each of these windows (y-axis, numbers not cumulative). Each bar is composed of four distinct groups: the percentage of PPIs with a single identified homologous PPI, the percentage with 2 to 10 homologous PPIs, the percentage with 11 to 100 homologous PPIs, and the percentage with more than 100 identified homologous PPIs.

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