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Table 1 Twenty-three p53-REs predicted positive by both p53MH and our algorithm

From: Regression based predictor for p53 transactivation

Gene chr p53-RE Start p53-RE End p53-RE_Dimer 1 p53-RE_Spacer p53-RE_Dimer 2 Spacer Length Ref.
PLK2 5 57793857 57793877 GGGCAAGTCC   AGGCATGTTT 0 [11]
PPM1J 1 113048061 113048081 GGGCTTGCTC   AGGCATGTTC 0 [25]
DDB2 11 47193105 47193126 GAACAAGCCC T GGGCATGTTT 1 [11]
KIAA1486 2 226209743 226209763 GAACATGCCT   GGGCTAGCCT 0 [11]
MTHFD1L 6 151220175 151220195 GGACATGCCT   GGGCATGTCC 0 [11]
PRKAG2 7 151016282 151016302 GAGCATGTCT   GAACATGTTC 0 [11]
AKAP6 14 31884451 31884471 AGACATGTTT   GGGCATGTCT 0 [25]
BIRC8 19 58490331 58490351 GGACATGCCT   GGGCATGTCT 0 [25]
APBB2 4 40721763 40721784 AAACTTGTTT C AGGCTAGCCC 1 [26]
TSHR 14 80618516 80618537 AAACTTGCTT C AAGCTAGCCC 1 [25]
DMD X 31592231 31592252 AAACATGCTC T GGACTAGCCT 1 [25]
SLCO2B1 11 74540123 74540146 GAGCAAGCCT GGG GGACATGTTC 3 [26]
ATF3 1 210865885 210865908 AGGCAAGTCC TCA GAGCATGTTT 3 [11]
FRMD4A 10 14167552 14167577 AAGCTTGCTT TCAGA GGGCTTGCCT 5 [11]
EGFR 7 55176461 55176487 AAACATGCCT TTCAAA GAACTAGTTC 6 [25]
MMP2 16 54067700 54067729 AGGCAAGTCC ATAAAGTGA AAGCAAGTTT 9 [11]
KRT15 17 36930241 36930270 GAACATGCCC TGTGAGCCT GAGCATGTTC 9 [25]
DLG2 11 83032605 83032636 GAACATGTCC ATGGCTGTCTC AGACTTGTTT 11 [25]
NRXN3 14 78316130 78316162 AGACTTGCCC AACTAGACATCA AGGCATGTTT 12 [25]
FHIT 3 61206990 61207024 AAACTTGCTT TCACTTTACTCTGT GGACTTGCCC 14 [26]
DOCK9 13 98270727 98270761 GGGCAAGTCC ACAGTGCAAAGTAA AAGCAAGTTT 14 [25]
GRIN2A 16 9796860 9796894 AAACTTGCTT TGACTTTACTCCAT GGACTTGCCC 14 [25]
ACCN1 17 28722009 28722043 AGGCAAGTCC GCAGTGCAAAGCGA AAGCAAGTTT 14 [25]
  1. These 23 top ranked REs had a p53MH score of 100 and a transactivation capability score of "4" by our algorithm. Of these, only 3 p53-REs (of genes PPM1J, DDB2 and PLK2; bold font) have been experimentally validated in previous studies.