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Table 2 Thirty-six non-coding SNPs overlapping with a validated p53-RE.

From: Regression based predictor for p53 transactivation

Genes p53 RE Location Spacer Length SNP ID Allele Wt-Binding Prediction Minor Allele-Binding Prediction Reference
SERTAD1 chr19: 45623874–45623893 0 rs268682 C/G 0 1 [7]
TAP1 chr6: 32929058–32929083 6 rs2228108 C/G 3 1 [10]
TP73 chr1: 3597020–3597050 11 rs12121865 A/G 2 3 [8, 10]
PLK2 chr5: 57793125–57793147 3 rs702720 A/G 1 2 [7, 9, 10]
HSP90AB1 chr6: 44322842–44322871 10 rs35074133 A/T 2 3 [10]
BDKRB2 chr14: 95740864–95740883 0 rs1800508 C/T 0 3 [9, 10]
DSCC1 chr18: 48118859–48118878 0 rs934345 C/G 2 3 [7]
TP73 chr1: 3556376–3556406 11 rs12040834 G/T 1 2 [10]
EEF1A1 chr6: 74286408–74286431 4 rs11550799 G/T 1 2 [9, 10]
EEF1A1 chr6: 74286408–74286431 4 rs11550790 G/T 1 2 [9, 10]
EEF1A1 chr6: 74286408–74286431 4 rs11556652 C/T 1 3 [9, 10]
EEF1A1 chr6: 74285585–74285606 2 rs11556679 C/G 1 1 [10]
EEF1A1 chr6: 74286408–74286431 4 rs11550844 C/T 1 1 [9, 10]
KRT8 chr12: 51585038–51585059 2 rs11554493 C/T 0 0 [10]
EEF1A1 chr6: 74285784–74285805 2 rs11556702 A/G 2 2 [10]
ADARB1 chr21: 45316682–45316701 0 rs2838769 A/G 2 2 [10]
SCGB1D2 chr11: 61765841–61765860 0 rs2232945 A/G 3 3 [7]
TP63 chr3: 190989527–190989549 3 rs9844460 C/T 4 4 [10]
EOMES chr3: 27739623–27739643 1 rs3806624 C/T 2 2 [7]
PMS2 chr7: 6012202–6012223 2 rs2881029 A/C 1 1 [7, 10]
SIVA chr14: 103984243–103984262 0 rs11628179 G/T 3 3 [7]
KRT8 chr12: 51585038–51585059 2 rs13098 A/T 0 0 [10]
PLK3 chr1: 45038183–45038202 0 rs17880745 A/T 2 2 [8]
PLK3 chr1: 45038183–45038208 6 rs17880745 A/T 2 2 [7, 10]
HSPA8 chr11: 122437379–122437406 8 rs11823704 A/C 0 0 [9, 10]
ARHGEF7 chr13: 110602821–110602840 0 rs1658728 G/T 3 3 [7]
RRM2B chr8: 103318244–103318263 0 rs28999675 C/G 4 4 [710]
TP73 chr1: 3556358–3556385 8 rs12040834 G/T 2 2 [10]
TP73 chr1: 3597020–3597039 0 rs12121865 A/G 3 3 [7]
EEF1A1 chr6: 74285784–74285805 2 rs11550818 C/T 2 2 [10]
TRIM22 chr11: 5668357–5668376 0 rs35926783 A/G 4 4 [10]
EDN2 chr1: 41720668–41720687 0 rs11572355 A/G 3 3 [7, 8, 10]
CASP1 chr11: 104411147–104411166 0 rs3809024 A/G 3 3 [7, 10]
HSPA8 chr11: 122437379–122437406 8 rs41302367 A/G On Spacer On Spacer [9, 10]
SLC38A2 chr12: 45037706–45037735 10 rs7960147 C/T On Spacer On Spacer [9, 10]
MSH2 chr2: 47483388–47483420 13 rs1863332 A/C On Spacer On Spacer [10]
  1. Of these, 33 SNPs overlap with dimers, out of which 10 SNPs were predicted to impact the transactivation capacity by our predictor (See Additional File 9 for more details).