Figure 1

Empirical distributions of ranking scores under the null hypothesis that 10 actives are uniformly distributed, 1000 compounds in total. (A) AU-ROC, smooth lines indicate normal distribution with mean = 0.5005 and variance = 0.0084; (B) RIE; (C) BEDROC; (D) pROC; (E) SLR, 10 × log(1000)-SLR is Gamma(10, 1) distributed; and (F) the perfect linear relationship between RIE and BEDROC.