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Table 2 Comparisons of the earliness of wSLR and BEDROC (α = 20) at different powers and number of actives, β = 0, 0.5, 1, 2, 5, 10, n = 5, 10, 20, 100.

From: A statistical framework to evaluate virtual screening

β 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
n = 5
0 0.44 0.44 0.47 0.47 0.47 0.61 0.66 0.66 0.66 0.67
0.5 0.50 0.50 0.50 0.50 0.50 0.58 0.62 0.62 0.62 0.62
1 0.53 0.53 0.49 0.49 0.49 0.55 0.58 0.58 0.58 0.58
2 0.60 0.60 0.48 0.48 0.48 0.50 0.52 0.52 0.52 0.52
5 0.65 0.65 0.40 0.40 0.40 0.40 0.42 0.42 0.42 0.43
10 0.65 0.65 0.34 0.34 0.34 0.34 0.36 0.36 0.36 0.38
n = 10
0 0.50 0.35 0.45 0.54 0.61 0.66 0.67 0.69 0.70 0.70
0.5 0.56 0.40 0.47 0.55 0.60 0.63 0.65 0.65 0.66 0.66
1 0.60 0.42 0.48 0.54 0.58 0.60 0.61 0.61 0.61 0.61
2 0.68 0.46 0.47 0.51 0.53 0.55 0.55 0.56 0.56 0.56
5 0.77 0.43 0.37 0.38 0.39 0.41 0.42 0.43 0.44 0.44
10 0.83 0.36 0.29 0.31 0.33 0.34 0.35 0.36 0.37 0.37
n = 20
0 0.40 0.38 0.50 0.58 0.65 0.69 0.71 0.72 0.72 0.72
0.5 0.46 0.41 0.51 0.58 0.63 0.65 0.67 0.67 0.67 0.67
1 0.48 0.44 0.51 0.56 0.60 0.61 0.61 0.62 0.62 0.62
2 0.55 0.46 0.49 0.53 0.55 0.56 0.57 0.57 0.57 0.57
5 0.60 0.41 0.40 0.42 0.44 0.46 0.46 0.47 0.47 0.47
10 0.56 0.33 0.30 0.32 0.33 0.36 0.37 0.38 0.39 0.39
n = 100
0 0.32 0.42 0.56 0.64 0.69 0.72 0.74 0.74 0.74 0.74
0.5 0.36 0.45 0.57 0.63 0.67 0.69 0.70 0.70 0.70 0.69
1 0.39 0.46 0.56 0.60 0.63 0.65 0.65 0.65 0.65 0.65
2 0.44 0.48 0.56 0.59 0.61 0.61 0.61 0.61 0.61 0.61
5 0.47 0.42 0.46 0.47 0.48 0.49 0.50 0.50 0.50 0.51
10 0.45 0.33 0.34 0.36 0.38 0.39 0.40 0.40 0.41 0.41
  1. The top early recognitions are represented as percentages.