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Figure 6 | BMC Bioinformatics

Figure 6

From: CLEAN: CLustering Enrichment ANalysis

Figure 6

Unsupervised selection of informative genes. Genes were clustered based on their expression across different tissue samples and functional coherence scores are calculated for the human and mouse datasets separately. Ability of different groups of genes to facilitate correct grouping of samples from the same tissue type in the combined human-mouse dataset was assessed by constructing ROC curves. The ROC curve for clustering samples based on all 10,287 genes is inserted in each plot (red line) for the reference. A) ROC curves for clustering samples based on genes with the statistically significant CLEAN scores in both mouse and human datasets, and genes not statistically significant in either of the datasets. B) Same as A) for the cwCLEAN instead of CLEAN scores. C) ROC curves based on genes selected using COPA. The number of selected genes was identical to the number of genes with statistically significant CLEAN scores used in A).

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