Figure 3

Predicted T on simulation data without and with group constraints. In the upper panel, we plotted the estimated concentrations of the three transcripts generated by Wang et al.'s deconvolution procedure without group constraints [36] (denoted by the circles). Note that every solution achieves a global minimum of the log-likelihood function, but they are quite different and none of them approximates the true T(denoted by the triangles). The lower panel shows the unique estimate using (four) group constraints; it is very close to the true T, even though the noise is large and there is some unknown background signal.