Identification of novel DNA repair proteins via primary sequence, secondary structure, and homology

BMC Bioinformatics

Table 4 Identification experiments using GO-UniProt data

Seq. Similarity	Pos/Neg (% Pos)	Methodolgy	AUC	TPR-0	TPR-1%	TPR-5%
		P-3	0.91	5.04	51.55	68.76
		PS-1–9	0.91	8.58	56.29	72.99
50% (Figure 2)	4580/9043 (34%)	PF-1	0.85	0.33	29.06	48.84
		BLAST	0.94	0.00	33.41	83.34
		PH-1	0.94	3.86	54.96	77.84
		PSH-1–9	0.94	7.40	55.07	80.41
		P-3	0.96	14.70	72.29	84.57
		PS-1–8	0.95	17.41	74.15	84.85
90%	11267/14257 (44%)	PF-3	0.86	3.83	37.13	50.30
		BLAST	0.97	0.00	47.56	92.36
		PH-3	0.97	20.13	67.81	84.49
		PSH-1–9	0.97	11.08	74.14	88.42
		P-3	0.98	23.40	82.09	91.12
		PS-3–9	0.97	24.23	81.38	89.63
0%	17828/19348 (48%)	PF-3	0.87	3.48	46.42	56.46
		BLAST	0.98	0.00	52.88	92.69
		PH-3	0.98	8.46	78.00	91.18
		PSH-1–9	0.98	4.31	80.45	92.06

The results (including Figure 2) of DNA repair protein identification experiments using proteins drawn from UniProt containing the DNA repair Gene Ontology.

ISSN: 1471-2105