The ordering of expression among a few genes can provide simple cancer biomarkers and signal BRCA1 mutations

BMC Bioinformatics

Table 1 Comparison of classification accuracies for a two-gene classifier, TSP, and a three-gene classifier, TST, for ten cancer studies.

Data Set	Leukemia	CNS	DLBCL	Colon	Prostate1	Prostate2	Prostate3	Lung	GCM	BRCA1
TST	98%	82%	95%	92%	93%	67%	95%	98%	82%	77%
TSP	91%	73%	98%	93%	89%	69%	91%	94%	79%	66%

The classification rates are estimated by leave-one-out cross validation. In both cases, the genes are restricted to a subset of differentially expressed genes based on a Wilcoxon rank test; the details appear in §2.3 and §3.1. The subsets are selected to ensure that the number of possible two-gene and three-gene classifiers are the same.

ISSN: 1471-2105