Figure 7

Different initial binding conformation of transition state of the CALB-D-phenylglycinemethylester complex. D-phenylglycinemethylester is covalently bound to Ser105. The two binding pockets are circled by dashed lines. (A) Initial binding conformation in which the larger part of the substrate binds into the larger pocket; (B) Initial binding conformation in which the larger part of the substrate binds into the smaller pocket.