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Figure 5 | BMC Bioinformatics

Figure 5

From: Integrative modeling of transcriptional regulation in response to antirheumatic therapy

Figure 5

Detail views of the network model shown in figure 3. (A) The modeling strategy takes into account that target genes of a transcription factor are often co-expressed. For example, all the genes that are regulated by HNF-1 are down-regulated after therapy onset. Outer parts are shown with lower opacity. (B) A set of genes associated with the GO category "immune system process" is predicted to contain TATA-like elements in their regulatory regions. (C) Three genes were expressed lower in responders at day 3 and all of them are regulated by NF-1 according to the model.

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