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Table 1 Evolutionarily conserved binding sites were found to be enriched for 12 TFs.

From: Integrative modeling of transcriptional regulation in response to antirheumatic therapy

TF Name

Transfac ID

Official Full Name

P-value

Expected Count

Count

TBP, TFIID

V$TBP_01, V$TATA_C, V$TATA_01

TATA box binding protein

0.0042

6.41

14

C/EBPbeta

V$CEBPB_01, V$CEBPB_02

CCAAT/enhancer binding protein beta

0.0112

5.03

11

Zic1, Zic3

V$ZIC1_01, V$ZIC3_01

Zic family member 1/3

0.0183

6.13

12

AP-2rep

V$AP2REP_01

Kruppel-like factor 12

0.0264

1.68

5

HNF-1, HNF-1A

V$HNF1_01, V$HNF1_C

HNF1 homeobox A

0.0274

2.30

6

Lmo2

V$LMO2COM_01, V$LMO2COM_02

LIM domain only 2

0.0352

5.98

11

SRY

V$SRY_02

sex determining region Y

0.0374

1.85

5

ATF-2

V$CREBP1_01

activating transcription factor 2

0.0408

1.30

4

Cart-1

V$CART1_01

ALX homeobox 1

0.0415

1.30

4

COMP1

V$COMP1_01

cooperates with myogenic proteins 1

0.0422

3.23

7

Hlf

V$HLF_01

hepatic leukemia factor

0.0470

1.97

5

NF-1, NF-1/L

V$MYOGNF1_01, V$NF1_Q6

nuclear factor I

0.0492

7.10

12

     

Σ = 96

  1. The column "Count" denotes the number of genes that possess a TFBS for the respective TF. All in all, 96 TF-gene interactions were predicted (GRN template).