From: Assessing the druggability of protein-protein interactions by a supervised machine-learning method
No. | Attribute |
---|---|
 | Structural information |
1 |    Pocket volume |
2 |    Accessible surface area of pocket |
3 |    Percentage of accessible surface area of pocket to that of total surface of protein |
4 |    Pocket compactness |
5 |    Pocket planarity |
6 |    d 1 +d 2 |
7 |    Pocket narrowness |
8 |    d 4 +d 5 |
9 |    Ratio of Ala frequency on pocket surface to that on total surface b |
10 |    Ratio of Cys frequency on pocket surface to that on total surface b |
11 |    Ratio of Asp frequency on pocket surface to that on total surface b |
12 |    Ratio of Glu frequency on pocket surface to that on total surface b |
13 |    Ratio of Phe frequency on pocket surface to that on total surface b |
14 |    Ratio of Gly frequency on pocket surface to that on total surface b |
15 |    Ratio of His frequency on pocket surface to that on total surface b |
16 |    Ratio of Ile frequency on pocket surface to that on total surface b |
17 |    Ratio of Lys frequency on pocket surface to that on total surface b |
18 |    Ratio of Leu frequency on pocket surface to that on total surface b |
19 |    Ratio of Met frequency on pocket surface to that on total surface b |
20 |    Ratio of Asn frequency on pocket surface to that on total surface b |
21 |    Ratio of Pro frequency on pocket surface to that on total surface b |
22 |    Ratio of Gln frequency on pocket surface to that on total surface b |
23 |    Ratio of Arg frequency on pocket surface to that on total surface b |
24 |    Ratio of Ser frequency on pocket surface to that on total surface b |
25 |    Ratio of Thr frequency on pocket surface to that on total surface b |
26 |    Ratio of Val frequency on pocket surface to that on total surface b |
27 |    Ratio of Trp frequency on pocket surface to that on total surface b |
28 |    Ratio of Tyr frequency on pocket surface to that on total surface b |
 | Drug and chemical information |
29 |    Number of small chemical drugs (L) d |
30 |    Number of small chemical drugs (S) e |
31 |    Number of biotech drugs (L) d |
32 |    Number of biotech drugs (S) e |
33 |    Number of approved drugs (L) d |
34 |    Number of approved drugs (S) e |
35 |    Number of experimental drugs (L) d |
36 |    Number of experimental drugs (S) e |
37 |    Number of investigational drugs (L) d |
38 |    Number of investigational drugs (S) e |
39 |    Number of nutraceutical drugs (L) d |
40 |    Number of nutraceutical drugs (S) e |
41 |    Number of withdrawn drugs (L) d |
42 |    Number of withdrawn drugs (S) e |
43 |    Number of illicit drugs (L) d |
44 |    Number of illicit drugs (S) e |
 | Functional information |
45 |    Both proteins are related to OMIM-registered diseases (1) or not (0) |
46 |    Number of interacting proteins (L) d |
47 |    Number of interacting proteins (S) e |
48 |    Number of biological pathways in which either protein is involved (L) d |
49 |    Number of biological pathways in which either protein is involved (S) e |
50 |    Number of biological pathways in which both interacting proteins are involved |
51 |    Identity scores of the GO terms in the Cellular Component category |
52 |    Identity scores of the GO terms in the Molecular Function category |
53 |    Identity scores of the GO terms in the Biological Process category |
54 |    Number of paralogs in the KEGG (L) d |
55 |    Number of paralogs in the KEGG (S) e |
56 |    Number of paralogs in the PIRSF (L) d |
57 |    Number of paralogs in the PIRSF (S) e |
58 |    Number of gene-expressing health states (L) d |
59 |    Number of gene-expressing health states (S) e |
60 |    Number of health states in which both genes are expressed |
61 |    Number of gene-expressing body sites (L) d |
62 |    Number of gene-expressing body sites (S) e |
63 |    Number of body sites in which both genes are expressed |
64 |    Number of gene-expressing developmental stages (L) d |
65 |    Number of gene-expressing developmental stages (S) e |
66 |    Number of developmental stages in which both genes are expressed |
67 |    Similarity scores of gene expression profiles in the Health State category |
68 |    Similarity scores of gene expression profiles in the Body Sites category |
69 |    Similarity scores of gene expression profiles in the Developmental Stage category |