Table 4 Potentially-druggable PPIs predicted by the SVM-based method. a
From: Assessing the druggability of protein-protein interactions by a supervised machine-learning method
PPI | PPI | ||
|---|---|---|---|
Protein 1 | Protein 2 | Protein 1 | Protein 2 |
APC | CTNNB1 | CTNNB1 | CTNNBIP1 |
ARHGAP1 | CDC42 | E2F2 | RB1 |
ARHGDIA | CDC42 | EGFR | ERRFI1 |
ARHGDIA | RAC1 | EP300 | CITED2 |
ARHGDIA | RAC2 | EP300 | HIF1A |
BCL2L1 | BECN1 | EP300 | MYB |
BCL9 | CTNNB1 | GSK3B | AXIN1 |
CALM1 | KCNN2 | HRAS | RALGDS |
CALM1 | RYR1 | HRAS | RASA1 |
CALM2 | MARCKS | MAX | MYC |
CD247 | SHC1 | NCF2 | RAC1 |
CDC42 | ITSN1 | NFKB1 | TXN |
CDC42 | MCF2L | NFKBIB | RELA |
CDC42 | WAS | RAC1 | ARFIP2 |
CDH1 | CTNNB1 | RAF1 | RAP1A |
CREBBP | CITED2 | RPA1 | TP53 |
CREBBP | HIF1A | S100B | TP53 |
CREBBP | IRF3 | SMAD2 | ZFYVE9 |
CREBBP | MYB | SMAD4 | SKI |
CTNNA1 | JUP | TP53 | TP53BP1 |
CTNNB1 | BTRC | TP53 | TP53BP2 |