Skip to main content
Figure 1 | BMC Bioinformatics

Figure 1

From: Global haplotype partitioning for maximal associated SNP pairs

Figure 1

Robustness of haplotype block partitioning. To assess the significance of a haplotype block partitioning algorithm, assume that the given samples establish a "founder" group apart from the main population. Both algorithms A and B find the same boundaries for haplotype blocks upon the "founder" sample (middle). If the population size is kept fixed, no mutation occurs and cross-overs happen only on boundaries of the blocks then after many generations all genotypes within the initial blocks stay the same while two locus alleles of SNP pairs between different blocks change. This results in different blocks by Algorithm A and the same block partitioning by Algorithm B (right). We call a block partitioning "robust" if the method reports the same block structure for haplotypes many generations after the "founder" haplotypes.

Back to article page