MultiLoc2 architecture. The architecture of MultiLoc2-HighRes (animal version). A query sequence is processed by a first layer of six subprediction methods (SVMTarget, SVMSA, SVMaac, PhyloLoc, GOLoc and MotifSearch). The two new subprediction methods, PhyloLoc and GOLoc, are highlighted in bold. The individual output of the methods of the first layer are collected in the protein profile vector (PPV), which enters a second layer of SVMs producing probability estimates for each localization.