Figure 1

Illustration of Epitopia's prediction for the 3D structure of the VEGF [PDB: 1BJ1, chain W]. (A) A sample of the immunogenicity and probability scores computed for each of the surface residues of the input structure. (B) The FirstGlance in Jmol interface presenting the color-coded immunogenicity scores projected onto the surface of the protein shown in spacefill. (C) Presentation of the VEGF structure, color-coded as in A, along with the backbones of the chains of its binding antibody [PDB: 1BJ1, chains L and H].