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Table 4 Identified protein domains of 6 hypothetical proteins

From: In Silico screening for functional candidates amongst hypothetical proteins

Accession Domain Description of protein domains
NP_001036096 Complex-1-LYR This hypothetical protein contains a Complex-1-LYR domain. The domain is present in a family of proteins, which include mitochondrial proteins from NADH-ubiquinone oxidoreductase complex 1. The domain is also present in the Saccharomyces cerevisiae protein Isd11, which is located in the mitochondrial matrix associated with the inner membrane. Isd11 protein is a subunit of the mitochondrial Fe/S protein biogenesis [26, 27]
NP_077025 Methyltransf 12 Methyltransferase 12 domain is present in proteins, which actively transfer methyl from ubiguitous S-adenosyl-L-methionine (SAM) to nitrogen, oxygen or carbon. This methyltrasferase domain is found in a variety of SAM-dependent methyltransferases including Coq3 methyltransferase, which is a mitochondrial protein involved in ubiquinone biosynthesis. Coq3 protein is located in the matrix of the mitochondria [28, 31, 32]
NP_055588 Sel1 Sel1 like repeats are tetratricopeptide repeats (TPR) identified in LIN-12 proteins of Caenorhabditis elegans as a negative regulator of the Notch pathway [33] TPR-repeats are found in a variety of proteins including eukaryotic chaperone complexes involving HSP70 and HSP90, and TPRs are also present in the mitochondrial Tom70 import receptor [29, 30]
EAW75090 DUF1640 DUF1640 domain is found in proteins of unknown functions. In Saccharomyces cerevisiae a protein containing the domain is named FMP32 (Found in mitochondrial proteome protein 32) and was localized to the mitochondria. []
NP_612455 DUF143 DUF143: This domain has no known function and is found in the iojap protein of maize. The protein has no known function [34]
EAW74251 Trm112p Trm112p is a zinc finger domain found in the TRM112 protein that is required for tRNA methylation in Saccharomyces cerevisae. [35]
  1. Description of protein domains identified in 6 hypothetical proteins of Group I, predicted to be expressed and to have a role in a mitochondrial context. In 4 out of 6 proteins, the identified protein domains have been described in experimentally characterized proteins of the mitochondria (First 4 domains).