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Table 4 Identified protein domains of 6 hypothetical proteins

From: In Silico screening for functional candidates amongst hypothetical proteins

Accession

Domain

Description of protein domains

NP_001036096

Complex-1-LYR

This hypothetical protein contains a Complex-1-LYR domain. The domain is present in a family of proteins, which include mitochondrial proteins from NADH-ubiquinone oxidoreductase complex 1. The domain is also present in the Saccharomyces cerevisiae protein Isd11, which is located in the mitochondrial matrix associated with the inner membrane. Isd11 protein is a subunit of the mitochondrial Fe/S protein biogenesis [26, 27]

NP_077025

Methyltransf 12

Methyltransferase 12 domain is present in proteins, which actively transfer methyl from ubiguitous S-adenosyl-L-methionine (SAM) to nitrogen, oxygen or carbon. This methyltrasferase domain is found in a variety of SAM-dependent methyltransferases including Coq3 methyltransferase, which is a mitochondrial protein involved in ubiquinone biosynthesis. Coq3 protein is located in the matrix of the mitochondria [28, 31, 32]

NP_055588

Sel1

Sel1 like repeats are tetratricopeptide repeats (TPR) identified in LIN-12 proteins of Caenorhabditis elegans as a negative regulator of the Notch pathway [33] TPR-repeats are found in a variety of proteins including eukaryotic chaperone complexes involving HSP70 and HSP90, and TPRs are also present in the mitochondrial Tom70 import receptor [29, 30]

EAW75090

DUF1640

DUF1640 domain is found in proteins of unknown functions. In Saccharomyces cerevisiae a protein containing the domain is named FMP32 (Found in mitochondrial proteome protein 32) and was localized to the mitochondria. [uniprot.org]

NP_612455

DUF143

DUF143: This domain has no known function and is found in the iojap protein of maize. The protein has no known function [34]

EAW74251

Trm112p

Trm112p is a zinc finger domain found in the TRM112 protein that is required for tRNA methylation in Saccharomyces cerevisae. [35]

  1. Description of protein domains identified in 6 hypothetical proteins of Group I, predicted to be expressed and to have a role in a mitochondrial context. In 4 out of 6 proteins, the identified protein domains have been described in experimentally characterized proteins of the mitochondria (First 4 domains).