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Table 9 Genotype relative risk evaluated from genotype distribution of SNPs in GYS2.

From: Detecting purely epistatic multi-locus interactions by an omnibus permutation test on ensembles of two-locus analyses

  

Frequency

  

SNP

Genotype

Case

Control

Relative Risk

95% CI

SNP9

0

0.6473

0.6575

0.9846

(0.9447-1.0262)

 

1

0.3167

0.3046

1.0396

(0.9558-1.1308)

 

2

0.0360

0.0379

0.9491

(0.7105-1.2679)

SNP10

0

0.5933

0.6441

0.9211

(0.8805-0.9634)

 

1

0.3712

0.3169

1.1713

(1.0839-1.2657)

 

2

0.0355

0.0389

0.9119

(0.6828-1.2180)

SNP11

0

0.6058

0.6142

0.9864

(0.9427-1.0321)

 

1

0.3507

0.3352

1.0461

(0.9675-1.1310)

 

2

0.0435

0.0506

0.8601

(0.6650-1.1126)

(SNP9, SNP10)

00

0.5863

0.6335

0.9255

(0.8841-0.9689)

 

01

0.0610

0.0240

2.5463

(1.9135-3.3885)

 

10

0.0055

0.0107

0.5166

(0.2610-1.0224)

 

11

0.3092

0.2919

1.0590

(0.9717-1.1540)

 

12

0.0020

0.0020

1.0018

(0.2831-3.5456)

 

21

0.0010

0.0010

1.0018

(0.1676-5.9902)

 

22

0.0335

0.0370

0.9071

(0.6734-1.2218)

(SNP10, SNP11)

00

0.5463

0.5922

0.9224

(0.8776-0.9695)

 

01

0.0455

0.0506

0.8997

(0.6982-1.1593)

 

02

0.0015

0.0013

1.1271

(0.2525-5.0304)

 

10

0.0595

0.0220

2.7095

(2.0164-3.6408)

 

11

0.3032

0.2823

1.0739

(0.9839-1.1722)

 

12

0.0085

0.0126

0.6723

(0.3805-1.1877)

 

21

0.0020

0.0023

0.8587

(0.2517-2.9296)

 

22

0.0335

0.0366

0.9153

(0.6791-1.2336)

  1. The explanation for how the relative risks are obtained and displayed is the same as that given in Table 3. The major/minor alleles for rs6487236, rs1871142 and rs10770836 are A/G, G/A and G/A, respectively. The allelic information is extracted from the original T2D data. SNP9 = rs6487236, SNP10 = rs1871142 and SNP11 = rs10770836.