Cumulative distribution function of a ratio of RCMAT and Kong et al . p-values under several simulated non-null conditions. For 12 non-null conditions 100 simulation experiments were performed and permutation p-values obtained for both the RCMAT and the method of Kong et al. The logarithm base ten of the RCMAT p-value/Kong et al. p-value ratio is listed on the horizontal axis. The vertical axis is the cumulative distribution function, the proportion of values less than the observed ratio, for the 100 simulated data sets within a condition.