Chemical | MOA | Occurrence | Causes | Examples of tumors |
---|---|---|---|---|
1,3-Butadiene | Genotoxic | Used in production of synthetic rubber. | Mutations | Leukemia |
Benzo(a)pyrene | Genotoxic | Incomplete burning of coal, oil and garbage. | Mutations | Skin, lung |
Diethylnitrosamine | Genotoxic | Found in foods, tobacco products and industrial solvents. | Mutations | Liver |
Styrene | Genotoxic | Used in the manufacture of plastics and rubber. | Mutations | Lung |
Chloroform | Non-genotoxic | Laboratory solvent and dry cleaning agent. | Cell death, regenerative proliferation. Hormonal receptor activation. | Liver, kidney |
Diethylstilbestrol | Non-genotoxic | Synthetic estrogen. | Â | Vagina, breast |
Fumonisin B1 | Non-genotoxic | A toxin produced by Fusarium moulds, found in foods. | Cell death, regenerative proliferation. | Oesophageal cancer, liver |
Phenobarbital | Non-genotoxic | Barbiturate used as anticonvulsant. | Stimulates proliferation inhibits apoptosis. | Liver (in laboratory animals) |