Table 3 The three gene pairs exhibiting the largest change in correlation with one another over lifespan for each differential coexpression coefficient are shown.

Lifestage

Gene 1

Gene 2

KEGG relationships

Lifelong change (+)

platelet-derived growth factor receptor, beta polypeptide

(PDGFRB) *

SHC (Src homology 2 domain containing) transforming protein 1

(SHC1)*

Focal adhesion

(hsa04510)

Glioma

(hsa05214)

Lifelong change (-)

prostaglandin E receptor 3 (subtype EP3)

(PTGER3)

abl-interactor 1

(ABI1)

Lifelong change (+)

hematopoietic cell-specific Lyn substrate 1

(HCLS1)

CD14 molecule

(CD14)*

Pathogenic Escherichia coli infection

(hsa05130)

Early life change (-)

eukaryotic translation elongation factor 1 alpha 1

(EEF1A1)*

exportin 5

(XPO5)

Early life change (-)

glutamate receptor, metabotropic 4

(GRM4)

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

(CACNA1A)*

Taste transduction

(hsa04742)

Early life change (-)

'6-pyruvoyltetrahydropterin synthase

(PTS)*

thioredoxin domain containing 9

(TXNDC9)

Late life change (+)

Janus kinase 1 (a protein tyrosine kinase)

(JAK1)

mitogen-activated protein kinase 9

(MAPK9)*

Pancreatic cancer

(hsa05212)

Late life change (-)

progesterone receptor membrane component 1

(PGRMC1)

ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)

(UBE2N)

Late life change (-)

neutral sphingomyelinase (N-SMase) activation associated factor

(NSMAF)

zinc finger protein 609

(ZNF609)