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Table 3 The three gene pairs exhibiting the largest change in correlation with one another over lifespan for each differential coexpression coefficient are shown.

From: A methodology for the analysis of differential coexpression across the human lifespan

Genes differentially coexpressed over age.
Lifestage Gene 1 Gene 2 KEGG relationships
Lifelong change (+) platelet-derived growth factor receptor, beta polypeptide
(PDGFRB) *
SHC (Src homology 2 domain containing) transforming protein 1
(SHC1)*
Focal adhesion
(hsa04510)
Glioma
(hsa05214)
Lifelong change (-) prostaglandin E receptor 3 (subtype EP3)
(PTGER3)
abl-interactor 1
(ABI1)
 
Lifelong change (+) hematopoietic cell-specific Lyn substrate 1
(HCLS1)
CD14 molecule
(CD14)*
Pathogenic Escherichia coli infection
(hsa05130)
Early life change (-) eukaryotic translation elongation factor 1 alpha 1
(EEF1A1)*
exportin 5
(XPO5)
 
Early life change (-) glutamate receptor, metabotropic 4
(GRM4)
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
(CACNA1A)*
Taste transduction
(hsa04742)
Early life change (-) '6-pyruvoyltetrahydropterin synthase
(PTS)*
thioredoxin domain containing 9
(TXNDC9)
 
Late life change (+) Janus kinase 1 (a protein tyrosine kinase)
(JAK1)
mitogen-activated protein kinase 9
(MAPK9)*
Pancreatic cancer
(hsa05212)
Late life change (-) progesterone receptor membrane component 1
(PGRMC1)
ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
(UBE2N)
 
Late life change (-) neutral sphingomyelinase (N-SMase) activation associated factor
(NSMAF)
zinc finger protein 609
(ZNF609)
 
  1. The timing and scale of change is listed in the first column, along with the direction of correlation change. The pairs of genes are listed in the second and third column, with asterisks to indicate membership in the GenAge database. The last column indicates if the genes are present in a common pathway from the KEGG database.