Method performances for different artificial signals, when class shows simultaneous up and down-regulation. Method performances for each proportion of signal representing part (Y axis) and signal magnitude (X axis) as measured by average AUC score. Score is also here shown by radius. Methods represented are the same as in the previous figure. Colouring (blue, cyan, green, yellow) again highlights the top methods. Dotted lines highlight the signal levels where the best method changes.