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Table 6 Comparison of GSZ and program packages using p53 dataset

From: Robust extraction of functional signals from gene set analysis using a generalized threshold free scoring function

 

GSZ-score

GSA

SP

GSEA

1

*BP:0001836: release of cytochrome c from mitochondria*

CC:0031903: micro-body membrane

CC:0009434: microtubule-based flagellum

CC:0000118: histone deacetylase complex

2

BP:0051668: localization within membrane

CC:0005778: peroxisomal membrane

MF:0005125: cytokine activity

BP:0009314: response to radiation

3

CC:0031903: micro-body membrane

CC:0009434: microtubule-based flagellum

CC:0019861: flagellum

BP:0050962: detection of light...

4

CC:0005778: peroxisomal membrane

CC:0044438: micro-body part

BP:0050962: detection of light...

BP:0050908: detection of light...

5

BP:0042787: protein ubiquitination...

CC:0044439: peroxisomal part

BP:0050908: detection of light...

BP: 0007602: phototransduction

6

*BP:0008637: apoptotic mitochondrial changes*

*BP:0001836: release of cytochrome c from mitochondria*

BP:0007602: phototransduction

BP:0009584: detection of visible light

7

CC:0044438: micro-body part

CC:0005626: insoluble Fraction

BP: 0009584: detection of visible light

BP:0009583: detection of light...

8

CC:0044439: peroxisomal part

CC:0019861: flagellum

*BP:0001836: release of cytochrome c from mitochondria*

MF:0030170: pyridoxal phosphate binding

9

CC:0009434: microtubule-based flagellum

MF:0015103: inorganic anion transmembrane...

BP:0009583: detection of light...

*BP:0001836: release of cytochrome c from mitochondria*

10

BP:0051205: protein insertion into mem brane

BP:0051668: localization within membrane

BP:0006955: immune response

MF:0005487: nucleocytoplasmic trans porter activity

11

BP:0046504: glycerol ether biosynthetic process

BP:0050962: detection of light...

BP:0030890: positive regulation of B cell proliferation

BP:0006654: phosphatidic acid biosynthetic process

12

BP:0045017: glycerolipid biosynthetic process

BP:0050908: detection of light...

MF:0001664: G-protein-coupled receptor binding

BP:0046473: phosphatidic acid metabolic process

13

BP:0008643: carbohydrate transport

BP:0007602: photo-transduction

BP:0006572: tyrosine catabolic process

BP:0035137: hindlimb morphogenesis

14

*BP:0008629: induction of apoptosis by intracellular signals*

BP:0009584: detection of visible light

MF:0008009: chemokine activity

BP:0051716: cellular response to stimulus

15

*BP:0008635: caspase activation via cytochrome c*

CC:0031594: neuromuscular junction

MF:0042379: chemokine receptor binding

BP:0008217: blood pressure regulation

  1. Table compares GSZ analysis with three popular software packages. Apoptosis related positive classes are highlighted as in table 5. GSZ, GSA and SP reported classes with strong signal, whereas GSEA did not report any significant classes. GSZ, GSA and SP reported strong p-value for GO class 1836, but only GSZ ranks it as top class. GSZ also reports 3 other apoptosis related classes.