Table 1 Cross-correlations of pathway genes with canonical variates of the remaining genes.
| Â | C1 | C2 | C3 | C4 | C5 | C6 | C7 | C8 | C9 |
|---|---|---|---|---|---|---|---|---|---|
AKT1 | -0.15 | -0.06 | 0.30 | 0.72 | 0.21 | 0.06 | -0.12 | 0.00 | 0.16 |
AKT2 | -0.03 | -0.18 | 0.08 | 0.46 | 0.25 | -0.24 | -0.05 | -0.24 | 0.17 |
ARAF | -0.53 | 0.28 | 0.23 | -0.01 | 0.12 | -0.07 | 0.32 | -0.14 | 0.05 |
CCND1 | -0.16 | -0.28 | 0.14 | -0.15 | 0.20 | 0.05 | -0.05 | -0.36 | -0.18 |
BRAF | 0.10 | 0.15 | 0.14 | 0.02 | 0.01 | -0.22 | -0.13 | 0.17 | -0.25 |
CAMK2A | 0.89 | 0.00 | 0.08 | -0.09 | -0.02 | 0.02 | 0.04 | 0.03 | 0.07 |
CAMK2D | -0.16 | 0.23 | 0.26 | -0.01 | 0.39 | 0.05 | -0.08 | -0.04 | 0.26 |
CAMK2G | 0.44 | -0.16 | -0.27 | 0.12 | -0.18 | 0.05 | -0.20 | 0.12 | -0.12 |
CDK6 | -0.28 | -0.09 | 0.31 | 0.06 | 0.51 | 0.12 | -0.18 | -0.19 | 0.14 |
CDKN1A | -0.10 | 0.63 | 0.04 | 0.03 | 0.52 | 0.13 | 0.13 | 0.09 | -0.10 |
CDKN2A | -0.21 | 0.74 | 0.29 | -0.22 | 0.11 | 0.04 | -0.03 | 0.02 | -0.10 |
E2F1 | -0.11 | -0.24 | 0.87 | 0.01 | -0.11 | 0.01 | -0.03 | -0.01 | -0.02 |
E2F3 | -0.21 | -0.16 | 0.61 | 0.22 | -0.18 | -0.02 | 0.23 | 0.04 | -0.12 |
EGF | -0.16 | 0.38 | -0.31 | -0.16 | 0.06 | -0.04 | 0.06 | 0.07 | -0.13 |
EGFR | -0.17 | -0.38 | 0.06 | 0.04 | 0.11 | -0.16 | 0.02 | 0.43 | 0.32 |
PTK2B | -0.06 | 0.15 | -0.09 | 0.71 | 0.03 | 0.08 | 0.11 | 0.18 | -0.01 |
FRAP1 | 0.33 | -0.13 | 0.05 | 0.07 | -0.28 | 0.05 | 0.10 | 0.51 | -0.14 |
GRB2 | 0.01 | 0.10 | -0.02 | 0.30 | 0.17 | -0.12 | 0.04 | -0.14 | 0.63 |
HRAS | 0.28 | 0.22 | 0.03 | -0.40 | 0.26 | -0.25 | -0.06 | 0.28 | 0.04 |
IGF1 | -0.01 | 0.73 | -0.17 | -0.14 | -0.05 | 0.11 | -0.07 | 0.30 | 0.14 |
IGF1R | -0.16 | -0.39 | -0.13 | -0.01 | 0.12 | 0.74 | -0.04 | -0.18 | -0.05 |
KRAS2 | 0.09 | 0.08 | 0.09 | -0.02 | -0.01 | -0.41 | 0.11 | 0.13 | -0.07 |
MDM2 | -0.18 | 0.24 | 0.10 | -0.04 | 0.11 | 0.01 | 0.61 | -0.01 | -0.12 |
PDGFA | -0.05 | 0.49 | 0.20 | -0.23 | 0.61 | 0.10 | 0.04 | -0.08 | 0.19 |
PDGFB | 0.24 | 0.24 | 0.13 | -0.01 | 0.19 | 0.05 | -0.11 | -0.02 | 0.02 |
PDGFRA | -0.01 | -0.36 | 0.26 | 0.04 | -0.05 | -0.05 | 0.12 | -0.25 | -0.24 |
PDGFRB | -0.03 | 0.35 | 0.15 | 0.39 | 0.27 | 0.11 | -0.12 | 0.21 | 0.13 |
PIK3CA | -0.19 | -0.23 | -0.09 | 0.14 | 0.33 | -0.39 | 0.06 | 0.05 | -0.21 |
PIK3CB | 0.25 | -0.01 | -0.12 | 0.29 | -0.10 | 0.07 | 0.05 | 0.08 | 0.20 |
PIK3CG | 0.00 | 0.24 | 0.08 | -0.10 | 0.17 | 0.16 | 0.00 | 0.12 | 0.15 |
PIK3R1 | 0.46 | -0.26 | -0.25 | -0.02 | -0.29 | -0.02 | -0.03 | 0.24 | 0.07 |
PLCG1 | -0.18 | -0.33 | 0.40 | -0.06 | 0.15 | 0.19 | -0.32 | 0.35 | -0.06 |
PLRG1 | 0.00 | -0.30 | -0.17 | 0.07 | 0.15 | -0.31 | 0.15 | 0.02 | -0.12 |
PRKCA | 0.23 | -0.29 | -0.25 | 0.61 | 0.17 | -0.07 | 0.02 | -0.18 | -0.21 |
PRKCB1 | 0.91 | 0.19 | -0.15 | 0.09 | 0.08 | 0.10 | 0.00 | -0.04 | 0.07 |
PRKCD | 0.20 | 0.80 | -0.13 | -0.07 | -0.07 | 0.00 | 0.02 | 0.09 | -0.09 |
PRKCG | 0.83 | 0.26 | -0.10 | 0.01 | -0.05 | 0.00 | -0.01 | 0.01 | -0.02 |
PRKCI | 0.31 | 0.11 | 0.31 | 0.07 | -0.05 | -0.11 | 0.02 | 0.36 | -0.24 |
MAPK1 | -0.02 | -0.21 | -0.24 | 0.23 | -0.13 | -0.13 | -0.18 | -0.06 | 0.16 |
MAP2K1 | 0.36 | 0.05 | -0.05 | -0.40 | -0.09 | -0.02 | 0.18 | -0.29 | -0.11 |
MAP2K2 | -0.21 | 0.20 | 0.14 | 0.04 | 0.27 | 0.25 | 0.03 | 0.25 | 0.33 |
PTEN | 0.13 | -0.01 | -0.48 | 0.00 | 0.13 | 0.14 | -0.09 | -0.25 | -0.12 |
RAF1 | -0.31 | -0.29 | -0.06 | 0.06 | -0.39 | -0.12 | -0.12 | -0.17 | 0.10 |
RB1 | -0.47 | 0.36 | 0.18 | -0.01 | 0.27 | -0.05 | 0.06 | -0.03 | 0.01 |
SHC1 | -0.29 | 0.58 | 0.20 | 0.11 | 0.38 | 0.12 | -0.11 | -0.03 | -0.02 |
SOS1 | 0.16 | -0.20 | -0.14 | 0.18 | 0.02 | -0.11 | 0.12 | -0.13 | -0.05 |
SOS2 | -0.37 | -0.20 | -0.26 | 0.02 | 0.04 | 0.03 | -0.04 | -0.21 | -0.07 |
TGFA | 0.22 | 0.13 | -0.23 | 0.05 | 0.44 | -0.23 | 0.31 | -0.31 | 0.13 |
TP53 | -0.40 | 0.20 | 0.35 | 0.02 | 0.23 | -0.06 | -0.16 | -0.10 | 0.02 |
SLC4A4 | 0.30 | -0.34 | -0.37 | 0.11 | 0.12 | -0.11 | -0.16 | 0.60 | 0.00 |
AKT3 | 0.40 | -0.37 | -0.30 | 0.21 | -0.13 | 0.04 | -0.12 | 0.00 | 0.10 |
RASSF1 | -0.32 | 0.53 | 0.17 | -0.36 | 0.11 | -0.07 | 0.04 | 0.12 | -0.24 |
SHC2 | 0.04 | -0.49 | -0.06 | -0.10 | 0.08 | -0.02 | -0.08 | -0.22 | -0.19 |
SHC3 | 0.38 | 0.14 | 0.04 | 0.04 | 0.28 | 0.07 | 0.14 | 0.15 | 0.00 |
RaLP | 0.08 | 0.12 | -0.24 | -0.03 | 0.42 | 0.30 | 0.10 | 0.08 | -0.08 |