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Table 2 Effective inhibitor concentrations necessary to kill Trypanosoma brucei.

From: TIde: a software for the systematic scanning of drug targets in kinetic network models

 

noncompetitive

uncompetitive

competitive

Glucose transport

1.09

1.27

6.13

Phosphoglycerate mutase

1.81

1.81

> 10000

Glyceraldehyde-3-p. dehydr.

2.89

5.32

6.17

Glycerol-3-p. dehydr.

3.79

3.88

253

Enolase

6.4

6.4

> 10000

Aldolase

8.14

8.36

319

  1. Shown are the concentrations required to reduce the flux through the upper glycolysis by 50% for different inhibition types and targets.