Prediction of protein-protein interaction types using association rule based classification

Park, Sung Hee; Reyes, José A; Gilbert, David R; Kim, Ji Woong; Kim, Sangsoo

doi:10.1186/1471-2105-10-36

BMC Bioinformatics

Table 7 Representative examples of ENZ type presenting different structural features

From: Prediction of protein-protein interaction types using association rule based classification

#	O	Rule description	Subtype	Conf	Supp	C	G	K	U	S	I
28	24	If NoHelix	ENZ_A, ENZ_B, ENZ_C	0.508	0.069	-	0.058	1	1	1	0.606
29	1	If SCOPClass = 7 AND NoHelix	ENZ_A, ENZ_B	1.000	0.032	1	0.315	1	1	1	0.764
30	17	If 461.83 ≤ df-ASA < 681.42 AND NoHelix	ENZ_A, ENZ_B	0.593	0.037	-	0.085	1	1	1	0.619
31	39	If 461.83 ≤ df-ASA < 681.42	ENZ_A, ENZ_B	0.477	0.111	1	0.076	-	-	-	0.416
32	16	If NoHelix AND nFrag < 4.75	ENZ_A	0.612	0.032	-	0.076	1	1	1	0.620
33	19	If 4.75 ≤ nSSE < 6.62 AND NoHelix	ENZ_A	0.588	0.032	-	0.072	1	1	1	0.538
34	51	If 461.83 ≤ df-ASA < 681.42 AND 4.75 ≤ nSSE < 6.62	ENZ_A	0.417	0.032	-	0.018	-	1	-	0.367
35	77	If 44.38 ≤ nAtom < 84.76 AND 461.83 ≤ df-ASA < 681.42	ENZ_A	0.396	0.058	-	0.023	-	-	-	0.159
36	34	If 9.58 ≤ nAA < 18.16 AND 44.38 ≤ nAtom < 84.76 AND 461.83 ≤ df-ASA < 681.42	ENZ_A	0.500	0.032	-	0.045	1	1	-	0.515
37	60	If 18.16 ≤ nAA < 26.74 AND 44.38 ≤ nAtom < 84.76	ENZ_A	0.357	0.032	-	0.015	-	1	-	0.351
38	10	If 84.76 ≤ nAtom < 125.14 AND 461.83 ≤ df-ASA <681.42	ENZ_B	0.617	0.053	1	0.145	1	1	-	0.636
39	13	If 12.66 ≤ sRatio < 15.06 AND 461.83 ≤ df-ASA < 681.42	ENZ_B	0.600	0.032	1	0.113	1	1	-	0.624
40	14	If 461.83 ≤ df-ASA < 681.42 AND 10.38 ≤ nSSE < 12.25 AND SCOPClass = 2	ENZ_B	0.857	0.032	-	0.230	1	1	-	0.624
41	27	If SCOPClass = 2 AND 461.83 ≤ df-ASA < 681.42 AND 84.76 ≤ nAtom < 125.14	ENZ_B	0.789	0.032	-	0.176	1	1	-	0.599
42	35	If 10.38 ≤ nSSE < 12.25 AND 12.25 ≤ nFrag < 16	ENZ_B	0.500	0.032	-	0.043	1	1	-	0.515
43	73	If 84.76 ≤ nAtom < 125.14 AND SCOPClass = 2	ENZ_B	0.408	0.042	-	0.043	-	-	-	0.164
44	114	If 84.76 ≤ nAtom < 125.14 AND 26.74 ≤ nAA < 35.32	ENZ_B	0.307	0.037	-	0.024	-	-	-	0.123
45	109	If 681.42 ≤ df-ASA < 901.01	ENZ_C	0.317	0.048	-	0.013	-	-	-	0.126
46	137	If 84.76 ≤ nAtom < 125.14 AND 681.42 ≤ df-ASA < 901.01	ENZ_C	0.252	0.032	-	0.009	-	-	-	0.098
47	146	If SCOPClass = 4	ENZ_C	0.221	0.042	-	0.011	-	-	-	0.091
48	101	If 35.32 901.01 nAA < 43.9 AND 125.14 ≤ nAtom < 165.52	ENZ_D	0.323	0.032	-	0.041	-	-	-	0.132
49	130	If SCOPClass = 3	ENZ_D	0.238	0.069	-	0.016	-	-	-	0.108
50	141	If 901.01 ≤ df-ASA < 1120.6	ENZ_D	0.207	0.032	-	0.050	-	-	-	0.096
51	54	If 1120.6 ≤ df-ASA < 1340.19	ENZ_E	0.392	0.042	-	0.018	-	1	-	0.363

Abbreviation of column names is the same as that of Table 6.
The ENZ subtypes are defined in Figure 4. Note that ENZ_B includes both inhibitors and enzymes while the others are exclusively formed by inhibitors (e.g. ENZ_A, ENZ_C and ENZ_E) or enzymes (e.g. ENZ_D).

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