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Figure 3 | BMC Bioinformatics

Figure 3

From: Elucidation of functional consequences of signalling pathway interactions

Figure 3

Network representation of isolated p53, NF-κB and cell cycle systems. A graphical representation of the (A) p53, (B) NF-κB, and (C) the G1/S transition phase of the cell cycle {RB_HUMAN, E2F1_HUMAN, CDN1B_HUMAN and CCND1_HUMAN} networks. The proteins are represented in the form of nodes, and their interactions in the form of edges. For the cell cycle network (C), the shared components linking RB_HUMAN, E2F1_HUMAN, CDN1B_HUMAN and CCND1_HUMAN to one another are highlighted (in green), and are six in number (i.e. three pairs). RB_HUMAN, CCND1_HUMAN and CDN1B_HUMAN connect with each other by CDK4_HUMAN and CDK2_HUMAN. RB_HUMAN, E2F1_HUMAN and CDN1B_HUMAN are linked together by CCNA1_HUMAN and SKP2_HUMAN. And finally RB_HUMAN, CDN1B_HUMAN, E2F1_HUMAN and CCND1_HUMAN link up with BRCA1_HUMAN and SP1_HUMAN as their connecting components.

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