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Table 8 Frequency and Biological process information on NF-κB and p53 networks connectors

From: Elucidation of functional consequences of signalling pathway interactions

Connector protein Frequency Biological process involved Protein in p53 Protein in NF-κB.
Heat shock protein HSP 90-beta (HS90B_HUMAN) 15   CD2A2_HUMAN TF65_HUMAN
    P53_HUMAN IKBB_HUMAN
Ubiquitin (UBIQ_HUMAN) 15 13 processes]: APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1-mediated degradation of Skp2; Apoptosis; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Cell Cycle Checkpoints; Cell Cycle, Mitotic; DNA Replication; HIV Infection; Regulation of activated PAK-2p34 by proteasome mediated degradation; Signalling by EGFR; Signalling by Wnt; Signalling in Immune system; Signalling by NGF MDM2_HUMAN RELB_HUMAN
    CDN1A_HUMAN NFKB2_HUMAN
Poly [ADP-ribose] polymerase 1 (PARP1_HUMAN) 10   CDN1A_HUMAN NFKB1_HUMAN
    P53_HUMAN IKKB_HUMAN
Stress-70 protein, mitochondrial (GRP75_HUMAN) 9   P53_HUMAN REL_HUMAN
    P53_HUMAN NFKB1_HUMAN
Heat shock cognate 71 kDa protein (HSP7C_HUMAN) 9 Membrane Trafficking P53_HUMAN IKBE_HUMAN
    P53_HUMAN IKKE_HUMAN
CREB-binding protein (CBP_HUMAN) 8 Gene Expression MDM2_HUMAN IKKA_HUMAN
    MDM2_HUMAN IKKB_HUMAN
Immunoglobulin heavy chain-binding protein (GRP78_HUMAN) 8 Hemostasis P53_HUMAN NFKB1_HUMAN
    P53_HUMAN NFKB2_HUMAN
Heat shock 70 kDa protein 1L (HS71L_HUMAN) 8   P53_HUMAN REL_HUMAN
    P53_HUMAN RELB_HUMAN
Heat shock protein HSP 90-alpha (HS90A_HUMAN) 7   P53_HUMAN IKBB_HUMAN
    P53_HUMAN IKBE_HUMAN
Nuclear receptor subfamily 3 group C member 1 (GCR_HUMAN) 7 Gene Expression MDM2_HUMAN NFKB1_HUMAN
    MDM2_HUMAN NFKB2_HUMAN