Elucidation of functional consequences of signalling pathway interactions

BMC Bioinformatics

Table 8 Frequency and Biological process information on NF-κB and p53 networks connectors

*Connector protein*	*Frequency*	*Biological process involved*	*Protein in p53*	*Protein in NF-κB*.
Heat shock protein HSP 90-beta (HS90B_HUMAN)	15		CD2A2_HUMAN	TF65_HUMAN
			P53_HUMAN	IKBB_HUMAN
Ubiquitin (UBIQ_HUMAN)	15	13 processes]: APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdh1-mediated degradation of Skp2; Apoptosis; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Cell Cycle Checkpoints; Cell Cycle, Mitotic; DNA Replication; HIV Infection; Regulation of activated PAK-2p34 by proteasome mediated degradation; Signalling by EGFR; Signalling by Wnt; Signalling in Immune system; Signalling by NGF	MDM2_HUMAN	RELB_HUMAN
			CDN1A_HUMAN	NFKB2_HUMAN
Poly [ADP-ribose] polymerase 1 (PARP1_HUMAN)	10		CDN1A_HUMAN	NFKB1_HUMAN
			P53_HUMAN	IKKB_HUMAN
Stress-70 protein, mitochondrial (GRP75_HUMAN)	9		P53_HUMAN	REL_HUMAN
			P53_HUMAN	NFKB1_HUMAN
Heat shock cognate 71 kDa protein (HSP7C_HUMAN)	9	Membrane Trafficking	P53_HUMAN	IKBE_HUMAN
			P53_HUMAN	IKKE_HUMAN
CREB-binding protein (CBP_HUMAN)	8	Gene Expression	MDM2_HUMAN	IKKA_HUMAN
			MDM2_HUMAN	IKKB_HUMAN
Immunoglobulin heavy chain-binding protein (GRP78_HUMAN)	8	Hemostasis	P53_HUMAN	NFKB1_HUMAN
			P53_HUMAN	NFKB2_HUMAN
Heat shock 70 kDa protein 1L (HS71L_HUMAN)	8		P53_HUMAN	REL_HUMAN
			P53_HUMAN	RELB_HUMAN
Heat shock protein HSP 90-alpha (HS90A_HUMAN)	7		P53_HUMAN	IKBB_HUMAN
			P53_HUMAN	IKBE_HUMAN
Nuclear receptor subfamily 3 group C member 1 (GCR_HUMAN)	7	Gene Expression	MDM2_HUMAN	NFKB1_HUMAN
			MDM2_HUMAN	NFKB2_HUMAN

ISSN: 1471-2105