Elucidation of functional consequences of signalling pathway interactions

BMC Bioinformatics

Table 9 Shortest paths

p53 network and cell cycle proteins
	Rb	E2F-1	P27	Cyclin D1
Direct link (l = 1)	2	2	0	1
Path with l = 2	44	17	31	25
Total shortest paths of all length l (l = 1, l = 2, l = 3, l = 4, ...)	46	19	31	26
NF-κB network and cell cycle proteins
	Rb	E2F-1	P27	Cyclin D1
Direct link (l = 1)	0	1	0	0
Path with l = 2	72	35	33	46
Total shortest paths of all length l (l = 1, l = 2, l = 3, l = 4, ...)	74	36	83	91

Path lengths with l = 1 is said to be a direct link. Total shortest path length is where l = 1, l = 2, l = 3 and l = 4

ISSN: 1471-2105