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Figure 1 | BMC Bioinformatics

Figure 1

From: An empirical Bayesian approach for model-based inference of cellular signaling networks

Figure 1

Schematic diagram of model developed for early EGF signaling. A schematic diagram of the biochemical events represented in the mathematical model represented using Systems Biology Graphical Notation [57]. The model represents ErbB1 synthesis and degradation; binding to EGF ligand; receptor dimerization and activation; activation of the signaling pathways associated with the binary interactions between ErbB1 + PLCγ-1, ErbB1 + Shc, Shc + Grb2, ErbB1 + Grb2, and Grb2 + Sos; deactivation following PTP + ErbB1 interactions; ligand-induced downregulation of ErbB1; Ras activation by ErbB1-bound Sos; and dissociation of active Shc.

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