Feasibility analysis of the adaptive response of yeast to heat shock. Feasibility analysis of the adaptive response of yeast to heat shock. Once the maximum and minimum regions that contain feasible solutions are found, a refined search is performed. For PFK the parameter set goes from 0.25 to 4.41. For TDH it goes from 1.35 to 11.86. For HXT it goes from 3 to 20. In each case, 10 segments are considered. Color code is as in Figure 5. Red circle: Maximum rate of ATP synthesis; Black circle: Maximum rate of NADPH synthesis; Gray circle: Maximum rate of Trehalose synthesis; Blue circle: Minimum cost; Black empty circles: Experimental observations (Table I in ).