Skip to main content

Table 1 Optimization of ethanol production.

From: Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses

Modified reaction numbers

(X i ) opt /(X i ) nom

LB (NLP)

UB (MILP)

Iterations

Total time (s)

HXT

[5]

72.68

72.77

4

2.05

HXT, PFK

[5,2.85]

103.66

103.86

3

2.64

All

[5,0.9,5,0.2,5,0.2,5,5]

157.59

157.70

4

0.89

HXT, GLK

[5,0.75]

72.68

72.77

4

1.32

HXT, PFK

[5,2.85]

103.66

103.86

3

0.57

HXT, GAPD

[5, 5]

73.18

73.31

4

1.22

HXT, PYK

[5,0.63]

72.68

72.77

4

1.25

HXT, TPS+GOL

[5,0.2]

73.41

73.54

4

1.24

HXT, GLY

[5, 5]

73.41

73.54

4

1.22

HXT, ATPase

[5, 5]

87.77

87.84

4

1.24

  1. Best optimization strategies for increasing the rate of ethanol production in the model discussed as case study 1 in [27]. LB: Lower bound, UB: Upper bound. Reaction numbers refer to the mathematical model used in [27]. HXT: Glucose uptake, GLK: Hexokinase, PFK: Phosphofructokinase, GAPD: Glyceraldehide-3-phosphate dehydrogenase, PYK: Pyruvate kinase, TPS+GOL: Polysaccharide production (glycogen + tre-halose), GLY: Glycerol production.