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Table 1 Optimization of ethanol production.

From: Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses

Modified reaction numbers (X i ) opt /(X i ) nom LB (NLP) UB (MILP) Iterations Total time (s)
HXT [5] 72.68 72.77 4 2.05
HXT, PFK [5,2.85] 103.66 103.86 3 2.64
All [5,0.9,5,0.2,5,0.2,5,5] 157.59 157.70 4 0.89
HXT, GLK [5,0.75] 72.68 72.77 4 1.32
HXT, PFK [5,2.85] 103.66 103.86 3 0.57
HXT, GAPD [5, 5] 73.18 73.31 4 1.22
HXT, PYK [5,0.63] 72.68 72.77 4 1.25
HXT, TPS+GOL [5,0.2] 73.41 73.54 4 1.24
HXT, GLY [5, 5] 73.41 73.54 4 1.22
HXT, ATPase [5, 5] 87.77 87.84 4 1.24
  1. Best optimization strategies for increasing the rate of ethanol production in the model discussed as case study 1 in [27]. LB: Lower bound, UB: Upper bound. Reaction numbers refer to the mathematical model used in [27]. HXT: Glucose uptake, GLK: Hexokinase, PFK: Phosphofructokinase, GAPD: Glyceraldehide-3-phosphate dehydrogenase, PYK: Pyruvate kinase, TPS+GOL: Polysaccharide production (glycogen + tre-halose), GLY: Glycerol production.